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CD278 (ICOS) Monoclonal Antibody (C398.4A), Functional Grade, eBioscience™, Invitrogen™
Armenian Hamster Monoclonal Antibody
Brand: Affymetrix eBioscience 16-9949-050
This item is not returnable.
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Description
The C398.4A MAb reacts with ICOS (Inducible Costimulatory molecule), also known as H4/CRP-1/AILIM, and cross-reacts with mouse and rat ICOS. ICOS is a T cell specific activation molecule and a third member of the CD28/CTLA-4 family. A dimer of 47-57 kDa, ICOS is expressed on activated T cells, has potent costimulatory activity for T cell activation and proliferation and is required for humoral immune response. ICOS binds to its ligand on activated APC including B cells called B7h/B7RP-1, is thought to play a protective role in inflammatory autoimmune diseases and be involved in the development of Th2 cells. C398.4A is reported to display strong costimulation of proliferation of T cell clones, intermediate costimulation on activated T cells, and weak costimulation on fresh resting T cells. It is a good costimulator of IL-10 production especially from pre-activated cells that express high level of H4/ICOS. The epitope recognized by C398.4A is different from that bound by the ICOSL (i.e., C398.4A does not block binding of ICOSL).
CD278 (ICOS) Monoclonal antibody specifically detects CD278 (ICOS) in Mouse, Rat, Rhesus Monkey samples. It is validated for Flow Cytometry, Functional Assay
Specifications
| CD278 (ICOS) | |
| Monoclonal | |
| 1 mg/mL | |
| PBS with no preservative; pH 7.2 | |
| Q9R1T7, Q9WVS0 | |
| Armenian Hamster | |
| 50 mg | |
| Primary | |
| Mouse, Rat, Rhesus Monkey | |
| Antibody | |
| IgG |
| Flow Cytometry, Functional Assay | |
| C398.4A | |
| Functional Grade | |
| ICOS | |
| Activation-inducible lymphocyte immunomediatory molecule; Ailim; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; CVID1; H4; Icos; inducible costimulator; inducible T cell costimulator; inducible T cell co-stimulator; inducible T-cell costimulator; inducible T-cell co-stimulator; Ly115 | |
| Affinity chromatography | |
| RUO | |
| 54167, 64545, 705788 | |
| 4° C | |
| Liquid |
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Product Title
CD278 (ICOS) Monoclonal Antibody (C398.4A), Functional Grade, eBioscience™, Invitrogen™ > 50 mg; Functional Grade
For Research Use Only
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