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STEMCELL Technologies SIS3
Activin/NODAL/TGF-β pathway inhibitor; Inhibits SMAD3
1269.95 NOK - 2237.52 NOK
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17120302
|
STEMCELL Technologies
73962 |
500 μg |
1269.95 NOK
500µg |
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|
17130302
|
STEMCELL Technologies
73964 |
1 mg |
2237.52 NOK
1mg |
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Description
- SIS3 (specific inhibitor of SMAD3) is a cell-permeable selective inhibitor of transforming growth factor β1 (TGF-β1)-dependent SMAD3 phosphorylation (IC50 = 3 μM) and SMAD3-mediated cellular signaling (Jinnin et al.) SIS3 has no effect on SMAD2, p38 mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK), or phosphoinositide 3-kinases
- Facilitates the production of anterior ectoderm from mouse induced pluripotent stem cells (Oshima et al.)
- Inhibits myofibroblast differentiation of normal human dermal fibroblasts (Jinnin et al.)
Specifications
| 1009104-85-1 | |
| C28H27N3O3 | |
| ≥98% |
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