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Tocris Bioscience™ PF 5274857 hydrochloride
High affinity and selective Smoothened (Smo) receptor antagonist
2380.00 NOK - 9230.00 NOK
Specifications
| Purity | >98% |
|---|---|
| Product Type | PF 5274857 hydrochloride |
| Molecular Weight (g/mol) | 473.42 |
| Inhibitors | PF 5274857 hydrochloride |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
18795578
|
Tocris Bioscience™
5262/10 |
10 mg |
2380.00 NOK
10mg |
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|
18734729
|
Tocris Bioscience™
5262/50 |
50 mg |
9230.00 NOK
50mg |
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Description
High affinity and selective Smoothened (Smo) receptor antagonist (Ki = 4.6 nM). Exhibits >1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes. Inhibits Shh-induced Hedgehog signaling in MEF cells. Induces tumor regression in a medulloblastoma allograft mouse model. Orally available and brain penetrant.Specifications
| >98% | |
| PF 5274857 hydrochloride | |
| 473.42 | |
| PF 5274857 hydrochloride |
For Research Use Only
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