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Tocris Bioscience™ PF 5274857 hydrochloride
High affinity and selective Smoothened (Smo) receptor antagonist
Brand: Tocris Bioscience™ 5262/50
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Description
PF 5274857 hydrochloride is a high affinity and selective Smoothened (Smo) receptor antagonist (Ki = 4.6 nM). Exhibits >1000-fold selectivity for Smo over a panel of other receptors, ion channels and enzymes. Inhibits Shh-induced Hedgehog signaling in MEF cells. Induces tumor regression in a medulloblastoma allograft mouse model. Orally available and brain penetrant.
Specifications
>98% | |
PF 5274857 hydrochloride | |
PF 5274857 hydrochloride |
50 mg | |
473.42 |
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Product Title
Tocris Bioscience™ PF 5274857 hydrochloride > 50mg
For Research Use Only
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