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STEMCELL Technologies Mouse Recombinant IL-10
Interleukin 10
Brand: STEMCELL Technologies 78079
This item is not returnable.
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Description
- Interleukin 10 (IL-10) is the founding member of the IL-10 family of class II cytokines
- All of the IL-10 cytokine family members have a four-helix bundle consisting of α-helical folds
- Upon binding to its receptor, IL-10 activates signaling through JAK1 and STAT3
- It is produced by dendritic cells, macrophages, and CD4+ T regulatory cells, as well as mast cells, NK cells, neutrophils, and regulatory B cells, under specific stimulating conditions
- IL-10 can inhibit the activation of certain immune cells while it promotes the function of B cells, and facilitates the healing process
- Specifically, this cytokine is important for the function of T regulatory cells as it is a potent suppressor of effector T cell proliferation and cytokine production
- Also, IL-10 produced by a subset of macrophages inhibits activation and production of pro-inflammatory cytokines by neighboring macrophages, thus allowing a level of self-regulation
Specifications
| B-TCGF, CSIF, Cytokine synthesis inhibitory factor, Interleukin-10, TGIF | |
| 10 μg | |
| Dendritic Cells; Hematopoietic Stem and Progenitor Cells; Myeloid Cells; Neurons; T Cells; T Cells, CD4+; T Cells, Regulatory | |
| ≥95% |
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