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CD123 (IL-3Rα) Mouse, anti-Human, Unconjugated, Clone: 6H6, STEMCELL Technologies
Mouse Monoclonal Antibody
1627.79 NOK - 2591.81 NOK
Specifications
| Antigen | CD123 (IL-3Rα) |
|---|---|
| Clone | 6H6 |
| Applications | Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence |
| Classification | Monoclonal |
| Conjugate | Unconjugated |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17109091
|
Stemcell Technologies
60110.1 |
25 μg |
1627.79 NOK
25µg |
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|
17199081
|
Stemcell Technologies
60110 |
100 μg |
2591.81 NOK
100µg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
- The 6H6 antibody reacts with human CD123 (IL-3 receptor subunit α), an ∼70 kDa type I transmembrane glycoprotein belonging to the type I cytokine receptor family (type 5 subfamily) and the immunoglobulin (Ig) superfamily
- CD123 constitutes the ligand-binding α chain of the heterodimeric IL-3 receptor
- CD123 binds IL-3 with low affinity per se, but when associated with CD131 (the signal-transducing β chain of the receptor), high-affinity binding of IL-3 is observed
- CD123 is expressed by hematopoietic progenitor cells, endothelial cells, basophils, eosinophils, mast cells, monocytes, macrophages, dendritic cells, megakaryocytes, a subset of B cells, and by neutrophils if cultured in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF)
- IL-3 binding to CD123 stimulates proliferation, differentiation, and viability of hematopoietic cells
- The 6H6 antibody does not inhibit binding of IL-3 to either CD123 or the IL-3 receptor
Specifications
| CD123 (IL-3Rα) | |
| Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence | |
| Unconjugated | |
| Rhesus Monkey, Sooty Mangabey, Human | |
| Primary |
| 6H6 | |
| Monoclonal | |
| Mouse | |
| IgG1 κ |
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