missing translation for 'onlineSavingsMsg'
Learn More
Learn More
CD123 (IL-3Rα) Mouse, anti-Human, Unconjugated, Clone: 6H6, STEMCELL Technologies
Mouse Monoclonal Antibody
Brand: Stemcell Technologies 60110
This item is not returnable.
View return policy
Description
- The 6H6 antibody reacts with human CD123 (IL-3 receptor subunit α), an ∼70 kDa type I transmembrane glycoprotein belonging to the type I cytokine receptor family (type 5 subfamily) and the immunoglobulin (Ig) superfamily
- CD123 constitutes the ligand-binding α chain of the heterodimeric IL-3 receptor
- CD123 binds IL-3 with low affinity per se, but when associated with CD131 (the signal-transducing β chain of the receptor), high-affinity binding of IL-3 is observed
- CD123 is expressed by hematopoietic progenitor cells, endothelial cells, basophils, eosinophils, mast cells, monocytes, macrophages, dendritic cells, megakaryocytes, a subset of B cells, and by neutrophils if cultured in the presence of granulocyte-macrophage colony-stimulating factor (GM-CSF)
- IL-3 binding to CD123 stimulates proliferation, differentiation, and viability of hematopoietic cells
- The 6H6 antibody does not inhibit binding of IL-3 to either CD123 or the IL-3 receptor
Specifications
| CD123 (IL-3Rα) | |
| Monoclonal | |
| Unconjugated | |
| 100 μg | |
| Rhesus Monkey, Sooty Mangabey, Human | |
| Dendritic Cells, Granulocytes and Subsets, Hematopoietic Stem and Progenitor Cells, Myeloid Cells |
| Immunohistochemistry, Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence | |
| 6H6 | |
| Mouse | |
| Primary | |
| IgG1 κ |
Product Content Correction
The Fisher Scientific Encompass Program offers items which are not part of our distribution portfolio. These products typically do not have pictures or detailed descriptions. However, we are committed to improving your shopping experience. Please use the form below to provide feedback related to the content on this product.
Product Title
Spot an opportunity for improvement?Share a Content Correction