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  8. WYE 687 dihydrochloride, Tocris Bioscience™

WYE 687 dihydrochloride, Tocris Bioscience™

Product Code. 30001505
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Quantity:
10 mg
50 mg
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Description

Potent and selective mTOR inhibitor

Potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC50 = 7 nM). Displays selectivity for mTOR over PI 3-Kα (∽100-fold) and PI 3-Kγ (∽500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1α expression. Exhibits antiproliferative effects in cancer cell lines through G1 cell cycle arrest and selective apoptosis.

Chemical Identifiers

CAS 1062161-90-3
Molecular Formula C28H32N8O3
Molecular Weight (g/mol) 528.617
InChI Key VDOCQQKGPJENHJ-UHFFFAOYSA-N
Synonym methyl n-4-4-morpholin-4-yl-1-1-pyridin-3-ylmethyl piperidin-4-yl pyrazolo 3,4-d pyrimidin-6-yl phenyl carbamate, pyrazolo pyrimidine, 9, methyl 4-4-morpholino-1-1-pyridin-3-ylmethyl piperidin-4-yl-1h-pyrazolo 3,4-d pyrimidin-6-yl phenyl carbamate, methyl 4-4-morpholin-4-yl-1-1-pyridin-3-yl methyl piperidin-4-yl-1h-pyrazolo 3,4-d pyrimidin-6-yl phenyl carbamate, methyl 4-4-morpholin-4-yl-1-1-pyridin-3-ylmethyl piperidin-4-yl-1hpyrazolo 3,4-d pyrimidin-6-yl phenyl carbamate
PubChem CID 25229450
IUPAC Name methyl N-[4-[4-morpholin-4-yl-1-[1-(pyridin-3-ylmethyl)piperidin-4-yl]pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]carbamate
SMILES COC(=O)NC1=CC=C(C=C1)C2=NC3=C(C=NN3C4CCN(CC4)CC5=CN=CC=C5)C(=N2)N6CCOCC6

Specifications

Quantity 50 mg
Formula Weight 601.53
Percent Purity >98%
Chemical Name or Material WYE 687 dihydrochloride
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