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Thiamet G, Tocris Bioscience™
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Quantity:
10 mg
Description
Potent, selective inhibitor of O-GlcNAcase (Ki = 21 nM for human O-GlcNAcase). Decreases the phosphorylation of tau protein in vivo. Promotes autophagy independently of mTOR pathway and reduces toxic protein species in mouse tauopathy model. Orally bioavailable and blood brain barrier permeable.
Specifications
Specifications
CAS | 1009816-48-1 |
Molecular Formula | C9H16N2O4S |
Quantity | 10 mg |
Synonym | thiamet g |
InChI Key | PPAIMZHKIXDJRN-LQOSVEJXSA-N |
SMILES | CCNC1=NC2C(C(C(OC2S1)CO)O)O |
IUPAC Name | (3aS,5R,6R,7S,7aS)-2-(ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol |
Molecular Weight (g/mol) | 248.297 |
PubChem CID | 122172999 |
Formula Weight | 248.3 |
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