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Tamoxifen, MP Biomedicals
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Quantity:
1 g
5 g
Description
- It has been used to facilitate the recombination of ect2flox allele in mouse organs.
- It has also been used to study its effect on lipopolysaccharide (LPS)-induced microglial activation.
- Protein kinase C inhibitor (IC50 = 50-200μM depending on assay conditions in MCF-7 cells or IC50 = 100μM in rat brain).
- It is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4.
Specifications
Specifications
Melting Point | 96°C to 100°C |
Color | White |
Loss on Drying | 0.0021 |
Refractive Index | KR5919600 |
Quantity | 5 g |
Synonym | [Z]-1-[p-Dimethylaminoethoxyphenyl]-1,2-diphenyl-1-butene, (Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine, ICI 47699, trans-Tamoxifen |
Solubility Information | Practically insoluble in water (< 0.01% at 20°C); soluble in methanol, ethanol, 2-propanol, propyleneglycol, chloroform (50mg/mL - clear, colorless to faint yellow solution) or DMSO |
IUPAC Name | (2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethyl)dimethylamine |
Physical Form | Powder |
Assay | 0.9935 |
Safety and Handling
Product Identifier
- Tamoxifen, Free Base
- Danger
- Carcinogenicity Category 1A
- Reproductive toxicity Category 1A
- H350-May cause cancer.
- H360-May damage fertility or the unborn child.
- P101-If medical advice is needed, have product container or label at hand.
- P102-Keep out of reach of children.
- P103-Read label before use.
- P263-Avoid contact during pregnancy/while nursing.
- P308+P313-IF exposed or concerned: Get medical advice/attention.
- P405-Store locked up.
- P501b-Dispose of contents/container in accordance with local/regional/national/international regulations.
- MIXTURE LIST-Contains : tamoxifen free base
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