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  6. SR 140333, Tocris Bioscience™

SR 140333, Tocris Bioscience™

Product Code. 18716937
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Quantity:
10 mg
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Description

Potent NK1 receptor antagonist

Potent NK1 receptor antagonist (Ki = 0.74 nM. IC50 = 1.6 nM). Inhibits substance P -invoked calcium mobilization and outward current (IC50 = 1.3 nM); blocks NK1-mediated nitric oxide-dependent vasodilation in vivo.

Chemical Identifiers

CAS 153050-21-6
Molecular Formula C37H45Cl3N2O2
Molecular Weight (g/mol) 656.129
InChI Key FQYWKNBGYHTSMN-SJYHNBSJSA-M
Synonym 1-[2-[(3S)-3-(3, 4-Dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride
PubChem CID 124080973
IUPAC Name 2-[(3R)-3-(3,4-dichlorophenyl)-3-[2-(4-phenyl-1-azoniabicyclo[2.2.2]octan-1-yl)ethyl]piperidin-1-yl]-1-(3-propan-2-yloxyphenyl)ethanone;chloride
SMILES CC(C)OC1=CC=CC(=C1)C(=O)CN2CCCC(C2)(CC[N+]34CCC(CC3)(CC4)C5=CC=CC=C5)C6=CC(=C(C=C6)Cl)Cl.[Cl-]

Specifications

Quantity 10 mg
Formula Weight 656.12
Percent Purity >97%
Chemical Name or Material SR 140333
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