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Retinoic Acid, All Trans Isomer, MP Biomedicals™
Mediates the functions of vitamin A required for growth and development. Retinoic Acid, All Trans Isomer, MP Biomedicals has been used in various differentiation protocols, including B-cells, T cells and neurons, and is applied clinically to treat cancer
Brand: MP Biomedicals 02190269.6
| Quantity | 50 mg |
|---|
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Description
Retinoic acid (RA) is a vitamin A-derived, non-peptidic, small lipophilic molecule. It affects gene transcription and modulates a wide variety of biological processes, including cell proliferation and differentiation, including apoptosis.
- Retinoic Acid mediated gene transcription depends on the rate of transport of Retinoic Acid to target cells and the timing of exposure of Retinoic Acid to RARs (Retinoic Acid Receptors) in the target tissues.
- All-trans-Retinoic acid (ATRA) is a ligand for both the retinoic acid receptor (RAR) and the retinoid X receptor (RXR).
- The bound RAR and RXR act as transcription factors that regulate the growth and differentiation of both normal and malignant cells.
- Cytochromes P450 (CYPs) catalyze the 4-hydroxylation of ATRA.
- Retinoic acid primes embryonic stem cells to become neurons.
Chemical Identifiers
| 302-79-4 | |
| 300.44 | |
| SHGAZHPCJJPHSC-YCNIQYBTSA-N | |
| 444795 | |
| C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O |
| C20H28O2 | |
| MFCD00001551 | |
| retinoic acid, tretinoin, vitamin a acid, all-trans-retinoic acid, trans-retinoic acid, renova, airol, retin-a, vesanoid, atra | |
| CHEBI:15367 |
Specifications
| 302-79-4 | |
| C20H28O2 | |
| 50 mg | |
| Soluble in methanol, chloroform (40mg/mL) or acetone (30mg/mL), slightly soluble in ethanol. | |
| C\C(\C=C\C1=C(C)CCCC1(C)C)=C/C=C/C(/C)=C/C(O)=O | |
| 300.44 | |
| CHEBI:15367 | |
| Powder |
| 173°C to 183°C | |
| MFCD00001551 | |
| retinoic acid, tretinoin, vitamin a acid, all-trans-retinoic acid, trans-retinoic acid, renova, airol, retin-a, vesanoid, atra | |
| SHGAZHPCJJPHSC-YCNIQYBTSA-N | |
| (2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid | |
| 444795 | |
| 300.4 |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
- Retinoic Acid, All Trans Isomer
Signal Word
- Danger
Hazard Category
- Acute toxicity Category 1
- Skin corrosion/irritation Category 2
Hazard Statement
- H300-Fatal if swallowed.
- H315-Causes skin irritation.
Precautionary Statement
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P310-IF SWALLOWED: Immediately call a POISON CENTER/doctor /
- P321-Specific treatment (see on this label).
- P332+P313-If skin irritation occurs: Get medical advice/attention.
- P405-Store locked up.
- P501-Dispose of contents/container to in accordance with local/regional/national/international regulations..
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Product Title
Retinoic Acid, All Trans Isomer, MP Biomedicals™ > 50mg
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