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Tocris Bioscience™ (R)-2-Hydroxyglutaric acid disodium salt, Tocris Bioscience™
KDM4A inhibitor; also NF-κB activator
Brand: Tocris Bioscience™ 6124/50
This item is not returnable.
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Description
(R)-2-Hydroxyglutaric acid disodium salt is an oncometabolite produced by mutant isocitrate dehydrogenase 1 (IDH1) and IDH2. Inhibits KDM4A in murine embryonic fibroblasts resulting in activation of mTOR. Also activates NF-κB in bone marrow stromal cells and inhibits FTO (mRNA N6-methyladenine demethylase).Specifications
| (R)-2-Hydroxyglutaric acid disodium salt | |
| (R)-2-Hydroxypentanedioic acid disodium salt | |
| Soluble to 100mM in water | |
| 192.08 | |
| White |
| 103404-90-6 | |
| 50 mg | |
| C5H6Na2O5 | |
| Solid | |
| Bioactive Small Molecule |
For Research Use Only.