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PYR 41, Tocris Bioscience™

Product Code. 18055582
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10mg
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This item is not returnable. View return policy

Description

Ubiquitin-activating enzyme (E1) inhibitor

Cell-permeable, irreversible ubiquitin-activating enzyme (E1) inhibitor (IC50 < 10 μM). Blocks ubiquitination and prevents ubiquitin-mediated proteasomal degradation. Inhibits NF-κB activation, blocks degradation of p53, increases p21 levels and induces apoptosis in vitro. Also causes an increase in sumoylation of proteins.

Specifications

CAS 418805-02-4
Molecular Formula C17H13N3O7
Quantity 10 mg
Synonym pyr-41, pyr 41, pyr41, ubiquitin e1 inhibitor, pyr-41, ethyl 4-4z-4-5-nitrofuran-2-yl methylidene-3,5-dioxopyrazolidin-1-yl benzoate, benzoic acid, 4-4-5-nitro-2-furanyl methylene-3,5-dioxo-1-pyrazolidinyl-, ethyl ester, 4-4-5-nitro-furan-2-ylmethylene-3,5-dioxo-pyrazolidin-1-yl-benzoic acid ethyl ester, 4 4-5-nitro-furan-2-ylmethylene-3,5-dioxo-pyrazolidin-1-yl-benzoic acid ethyl ester
InChI Key ARGIPZKQJGFSGQ-LCYFTJDESA-N
SMILES CCOC(=O)C1=CC=C(C=C1)N2C(=O)C(=CC3=CC=C(O3)[N+](=O)[O-])C(=O)N2
IUPAC Name ethyl 4-[(4Z)-4-[(5-nitrofuran-2-yl)methylidene]-3,5-dioxopyrazolidin-1-yl]benzoate
Molecular Weight (g/mol) 371.305
PubChem CID 5335621
Formula Weight 371.3
Percent Purity >98%
Chemical Name or Material PYR 41
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