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Merck Millipore Proteinase K
From Tritirachium album
Brand: Merck Millipore 1245680500
This item is not returnable.
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Description
- Chromatographically purified lyophilized 30 m Anson-U/mg
- For biochemistry and molecular biology EC 3.4.21.14
- Useful for the proteolytic inactivation of nucleases during the isolation of DNA and RNA.
- Removes endotoxins that bind to cationic proteins such as lysozyme and ribonuclease A.
- Reported useful for the isolation of hepatic, yeast, and mung bean mitochondria
- Determination of enzyme localization on membranes
- Treatment of paraffin embedded tissue sections to expose antigen binding sites for antibody labeling.
- Digestion of proteins from brain tissue samples for prions in Transmissible
- Spongiform Encephalopathies (TSE) research.
- Proteinase K is a stable and highly reactive serine protease.
- Evidence from crystal and molecular structure studies indicates the enzyme belongs to the subtilisin family with an active-site catalytic triad (Asp39-His69-Ser224).
- It is stable in a broad range of environments: pH, buffer salts, detergents (SDS), and temperature.
- In the presence of 0.1-0.5% SDS, proteinase K retains activity and will digest a variety of proteins and nucleases in DNA preparations without compromising the integrity of the isolated DNA.
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- PROTEINASE K CHROMATOgrAPHICALLY PURIFIED, 500mg
Signal Word
- Danger
Hazard Category
- Serious eye damage/eye irritation Category 2
- Respiratory sensitiser Category 1
- Skin corrosion/irritation Category 2
Hazard Statement
- H315-Causes skin irritation.
- H319-Causes serious eye irritation.
- H334-May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Precautionary Statement
- P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
- P264-Wash skin thoroughly after handling.
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P302+P352-IF ON SKIN: Wash with plenty of water/.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P305+P351+P338-IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
- P312-Call a POISON CENTER/doctor/if you feel unwell.
Supplemental information
- MIXTURE LIST-Contains : proteinase k
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