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  6. Progesterone, 98%, Thermo Scientific Chemicals

Progesterone, 98%, Thermo Scientific Chemicals

Product Code. 10368310
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Quantity:
5 g
25 g
100 g
Packaging:
Glass bottle
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Progesterone, CAS # 57-83-0, is a naturally occurring hormone required for maintenance of the uterine endothelium and suppression of estrogens.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Progesterone is a sex hormone required for suppression of estrogen signaling and is also involved in transcriptional activation

• Progesterone maintains the uterine endothelium and sustains pregnancy through suppression of muscle contractility

Applications

• Progesterone signaling is relevant to the study of breast cancer

Literature References

Kim, O.; Park, E.Y.; Kwon, S.Y.; Shin, S.; Emerson, R.E.; Shin, Y.H.; DeMayo, F.J.; Lydon, J.P.; Coffey, D.M.; Hawkins, S.M.; Quilliam, L.A.; Cheon, D.J.; Fernández, F.M.; Nephew, K.P.; Karpf, A.R.; Widschwendter, M.; Sood, A.K.; Bast, R.C. Jr.; Godwin, A.K.; Miller, K.D.; Cho, C.H.; Kim, J. Targeting progesterone signaling prevents metastatic ovarian cancer. Proc Natl Acad Sci U S A. 2020, 117(50), 31993-32004.

Jain, V.; McDonald, S.D.; Mundle, W.R.; Farine, D. Guideline No. 398: Progesterone for Prevention of Spontaneous Preterm Birth. J Obstet Gynaecol Can. 2020, 42(6), 806-812.

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 57-83-0
Molecular Formula C21H30O2
Molecular Weight (g/mol) 314.46
MDL Number MFCD00003658
InChI Key RJKFOVLPORLFTN-LEKSSAKUSA-N
Synonym progesterone, agolutin, luteohormone, pregn-4-ene-3,20-dione, crinone, 4-pregnene-3,20-dione, corpus luteum hormone, progestin, syngesterone, utrogestan
PubChem CID 5994
ChEBI CHEBI:17026
IUPAC Name (8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
SMILES CC(=O)C1CCC2C1(CCC3C2CCC4=CC(=O)CCC34C)C

Specifications

Melting Point 126°C to 131°C
Color Brown-Yellow to Yellow
Loss on Drying 0.5% max. (500 mg, 105°C, 2 hrs)
Infrared Spectrum Authentic
Assay Percent Range 97.5% min. (HPLC)
Packaging Glass bottle
Quantity 5 g
Merck Index 15, 7889
Specific Rotation Condition +190° (20°C c=1,ethanol)
Specific Rotation + 190
Solubility Information Solubility in water: insoluble. Other solubilities: soluble in alcohol,acetone,dioxane,conc. h2so4
Formula Weight 314.46
Percent Purity 98%
Physical Form Crystalline Powder, Crystals or Chunks
Chemical Name or Material Progesterone
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Safety and Handling

compliance-icons
Product Identifier
  • Progesterone
 Signal Word
  • Warning
 Hazard Category
  • Carcinogenicity Category 2
 Hazard Statement
  • H351-Suspected of causing cancer.
 Precautionary Statement
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.

RUO – Research Use Only

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