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Thermo Scientific™ Pierce™ Traut's Reagent (2-iminothiolane)
2-Iminothiolane-HCl (CAS 4781-83-3); an amine-reactive thiolation reagent to cap protein primary amines with sulfhydryl groups for immediate crosslinking.
Brand: Thermo Scientific™ 26101
Description
Thermo Scientific™ Pierce Traut's Reagent is 2-iminothiolane, a small thiolation compound that reacts with primary amines (e.g., lysine side chains) to add a small spacer arm (8.1 Ås) terminated by a free sulfhydryl group.
Highlights:
- Reacts with primary amines (lysine epsilon amino groups) at pH 7-9
- Adds a short spacer ending in a sulfhydryl group, ready for use as a target for sulfhydryl-specific crosslinking or labeling
- Amine-containing spacer arm preserves charge of original, modified primary amine

Specifications
Amine | |
Sulfhydryl Group | |
Pierce™ | |
Powder | |
DMF, DMSO |
Storage: Upon receipt store product at 4°C with desiccant. Product shipped at ambient temperature | |
Conjugating Groups | |
Short (<10 Å) | |
500 mg | |
Thiophilic Adsorption Kit |
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