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Thermo Scientific™ Sulfo-LC-SPDP (sulfosuccinimidyl 6-(3'-(2-pyridyldithio)propionamido)hexanoate)
Crosslink amines to sulfhydryls with this water-soluble sulfo-NHS-ester and pyridyldithiol groups on 10-atom spacer arms to form cleavable disulfide bonds with cysteines.
Brand: Thermo Scientific™ 21650
Description
Thermo Scientific™ Pierce Sulfo-LC-SPDP is a water-soluble, long-chain crosslinker for amine-to-sulfhydryl conjugation via NHS-ester and pyridyldithiol reactive groups that form cleavable (reducible) disulfide bonds with cysteines.
Highlights:
- Forms cleavable disulfide bonds with sulfhydryls
- Releases a detectable byproduct after reacting with free sulfhydryl groups; by measuring the release of pyridine-2-thione at 343nm, the reaction progression can be monitored
- Reactive groups: sulfo-NHS ester and pyridyldisulfide
- Reactive toward: amino and sulfhydryl groups

Specifications
Amine-Sulfhydryl | |
Sulfo-LC-SPDP | |
No | |
Upon receipt store at -20°C protected from moisture. | |
Ambient | |
Chemical Labeling | |
Pyridyldisulfide, Sulfo-NHS Ester | |
Powder | |
Water | |
Yes |
By Thiols | |
527.57 | |
15.7 Å | |
No | |
Pierce™ | |
Heterobifunctional | |
Medium (10 to 30 Å) | |
50 mg | |
Standard | |
Crosslinker |
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For Research Use Only. Not for use in diagnostic procedures.