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Thermo Scientific™ SDA (NHS-Diazirine) (succinimidyl 4,4'-azipentanoate) Product Code.: 11891415

Thermo Scientific™ SDA (NHS-Diazirine) (succinimidyl 4,4'-azipentanoate)

Product Code. 11891415 Shop All Thermo Scientific Products
50 mg, 50mg
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Quantity:
50 mg
Unit Size:
50mg
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Product Code. 11891415

Brand: Thermo Scientific™ 26167

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This item is not returnable. View return policy

Very short to mid-length (3.9 to 13.5A), amine-to-anything crosslinkers; NHS-ester and diazirine reactive groups; photoactivate with UV light (Amax 330 to 370nm).

Thermo Scientific™ Pierce NHS-Diazirine Crosslinkers combine proven NHS-ester and diazirine-based photoreaction chemistries to conjugate amine-containing molecules with nearly any other functional group via long-wave UV-light activation.

The succinimidyl-ester diazirine (SDA) reagents are a new class of crosslinkers that combine proven amine-reactive chemistry with an innovative and efficient diazirine-based photochemistry for conjugating amine-containing molecules to nearly any other functional group. The SDA crosslinkers include six compounds differing in spacer arm lengths, ability to cleave the crosslinked proteins, and presence or absence of a charged group for membrane permeability. Protein crosslinking is an important technique used to understand protein structure and to stabilize protein-protein interactions. Thermo Scientific SDA Reagents extend the efficiency and range of interactions that can be explored by this approach.

Highlights:

  • Versatile - different amine-reactive diazirine derivatives capture specific intracellular or cell-surface protein interactions

  • Controllable - two-step chemical crosslinking is activated using common laboratory UV lamps

  • Reversible - disulfide-containing spacers enable cleavage using reducing agents

  • Easy - reagents are photo-stable under typical laboratory lighting conditions so there is no need to perform experiments in the dark

  • Better than aryl azides - diazirine photo-reactive group has better photostability and is more efficiently activated by long-wave UV light

TRUSTED_SUSTAINABILITY

Specifications

Chemical Reactivity Amine-Nonselective
Cleavable No
Description SDA
Molecular Weight (g/mol) 225.2
PEGylated No
Spacer Arm Length 3.9 AĚŠ
Content And Storage Upon receipt store product at 4°C protected from light and moisture.
Cell Permeability Yes
Shipping Condition Ambient
Product Line Pierce™
Labeling Method Chemical Labeling
Crosslinker Type Heterobifunctional
Reactive Moiety NHS Ester, Diazirine
Spacer Short (<10 AĚŠ)
Form Solid
Quantity 50 mg
Solubility DMF, DMSO
Format Standard
Water Soluble No
Product Type Crosslinker
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Certificates

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5 results found
Lot Number Certificate Type Date Product Code
Lot NumberZJ389956 Certificate TypeCertificate of Analysis Date16/12/2024 Product Code26167
Lot NumberZE388161 Certificate TypeCertificate of Analysis Date14/06/2024 Product Code26167
Lot NumberZB384790 Certificate TypeCertificate of Analysis Date14/02/2024 Product Code26167
Lot NumberYL383748 Certificate TypeCertificate of Analysis Date25/01/2024 Product Code26167
Lot NumberYJ381423 Certificate TypeCertificate of Analysis Date02/11/2023 Product Code26167

For Research Use Only. Not for use in diagnostic procedures.

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