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DiscoverX PathHunter™ eXpress CCR4 Total GPCR Internalization Assay
The PathHunter™ eXpress CCR4 Total GPCR Internalization Assay measures CCR4 (GPCR) internalization via early-endosome localization. eXpress kits contain all assay materials: cells, reagents, and plates.
Brand: DiscoverX 93-0845E3CP27L
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Description
The PathHunter™ CCR4 Total GPCR internalization eXpress kit provides an easy to-use cell based assay to study drug candidates (small molecules or biologics) affecting GPCR activation and internalization. This kit assesses ligand (e.g. CCL22/MDC) based internalization of CCR4 via detection of localization to the early endosome. This product uses EFC technology. The included cells overexpress PK-tagged CCR4 and an EA-tagged early endosome protein. Upon ligand-induced receptor activation, resulting internalization of the CCR4 receptor to the early endosome leads to production of EFC signal. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates.Specifications
| GPCR | |
| 1,000 dp (10 x 96-well) | |
| CCR4 |
| Assay-Ready eXpress Kits | |
| CCR4 |
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DiscoverX PathHunter™ eXpress CCR4 Total GPCR Internalization Assay
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