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  6. Okadaic acid, 98%, Thermo Scientific Chemicals

Okadaic acid, 98%, Thermo Scientific Chemicals

Product Code. 15402979
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Quantity:
100 μg
300 μg
50 μg

Description

Okadaic acid, is used as an activator of PKC and inhibitor of PP1 and PP2A phosphatases. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. It is shown to activate atypical protein kinase C in adipocytes.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Okadaic acid, is used as an activator of PKC and inhibitor of PP1 and PP2A phosphatases. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. It is shown to activate atypical protein kinase C in adipocytes.

Solubility
It is soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (≥1 mg/ml), chloroform, acetone, ethyl acetate, DMF, and dimethylsulfoxide. Insoluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away fom strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 78111-17-8
Molecular Formula C44H68O13
Molecular Weight (g/mol) 805.015
MDL Number MFCD00083455
InChI Key QNDVLZJODHBUFM-ZJOMISMMSA-N
Synonym okadaic acid
PubChem CID 131839562
IUPAC Name (2R)-3-[(2S,6R,8S,11R)-2-[(E)-4-[(2R,4R,4aS,6R,8aR)-4-hydroxy-2-[(1S,3S)-1-hydroxy-3-[(2R,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-11-hydroxy-4-
SMILES CC1CCC2(CCCCO2)OC1C(C)CC(C3C(=C)C(C4C(O3)CCC5(O4)CCC(O5)C=CC(C)C6CC(=CC7(O6)C(CCC(O7)CC(C)(C(=O)O)O)O)C)O)O

Specifications

Color White
Quantity 100 μg
UN Number UN3462
Merck Index 14,6819
Solubility Information It is soluble in ethanol (25mg/ml),DMSO (25mg/ml),methanol (<1mg/ml),chloroform,acetone,ethyl acetate,DMF,and dimethylsulfoxide. Insoluble in water,unless first dissolved in organic solvents,such as DMSO or ethanol.
Formula Weight 805.02
Percent Purity 98%
Physical Form Powder
Chemical Name or Material Okadaic acid

RUO – Research Use Only

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