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  8. NSC 74859, Tocris Bioscience™

NSC 74859, Tocris Bioscience™

Product Code. 30001646
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Quantity:
10 mg
50 mg
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Description

Selective STAT3 inhibitor

NSC 74859 selectively inhibits STAT3 DNA-binding activity in vitro (IC50 values are 86, 160, and >300 μM for STAT3-STAT3, STAT1-STAT3 and STAT1-STAT1 DNA-binding activity respectively). NSC 74859 blocks growth and induces apoptosis preferentially in tumor cells that contain persistently active STAT3 in vitro and arrests tumor growth in a murine xenograft model in vivo.

Chemical Identifiers

CAS 501919-59-1
Molecular Formula C16H15NO7S
Molecular Weight (g/mol) 365.356
InChI Key HWNUSGNZBAISFM-UHFFFAOYSA-N
Synonym 2-hydroxy-4-2-tosyloxy acetamido benzoic acid, unii-jg1e8503oi, stat3 inhibitor vi, s3i-201, salicylic acid, 4-p-toluenesulfonate, 2-hydroxy-4-2-4-methylphenyl sulfonyl oxy acetyl amino benzoic acid, 2-hydroxy-4-2-4-methylbenzenesulfonyl oxy acetamido benzoic acid, benzoic acid, 2-hydroxy-4-2-4-methylphenyl sulfonyl oxy acetyl amino, s3i hplc, 2-hydroxy-4-2-p-tolylsulfonyloxy acetyl amino benzoic acid
PubChem CID 252682
IUPAC Name 2-hydroxy-4-[[2-(4-methylphenyl)sulfonyloxyacetyl]amino]benzoic acid
SMILES CC1=CC=C(C=C1)S(=O)(=O)OCC(=O)NC2=CC(=C(C=C2)C(=O)O)O

Specifications

Quantity 10 mg
Formula Weight 365.36
Percent Purity >98%
Chemical Name or Material NSC 74859
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