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Tocris Bioscience™ NICE 01
Heterobifunctional compound for nuclear import of FKBPF36V tagged proteins
Brand: Tocris Bioscience™
4520.51 NOK valid until 2024-12-16
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This item is not returnable.
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Description
NICE 01 is a bifunctional molecule consisting of (+)-JQ1 (Cat. No. 4499) and AP 1867 (Cat. No. 6207), with a PEG2-diamine linker. It has a high affinity (Kd = 94 pM) for FKBPF36V tagged proteins. It can induce nuclear localization of cytosolic proteins and target transcriptional regulation. It can be used to calculate the kinetic constant and passive diffusion across the nuclear pore.Specifications
| (R)-1-(3-((14-((S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-2,13-dioxo-6,9-dioxa-3,12-diazatetradecyl)oxy)phenyl)-3-(3,4-dimethoxyphenyl)propyl (S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2- | |
| Protein Dimerizers | |
| 98% |
| 5 mg | |
| C63H76ClN7O13S |