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NF 023, Tocris Bioscience™

Product Code. 18074562
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Quantity:
10 mg
50 mg
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Description

Selective and competitive P2X1 antagonist

A subtype-selective, competitive and reversible P2X1 receptor antagonist. Displays IC50 values of 0.21, 28.9, > 50 and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively. Selective over adrenoceptors, histamine and P2Y receptors. Also selectively inhibits the α-subunit of Go/i (EC50 ∽300 nM). Also inhibits DNA-binding activity of HMGA2 (IC50 = 10.63 μM).

Chemical Identifiers

CAS 104869-31-0
Molecular Formula C35H20N4Na6O21S6
Molecular Weight (g/mol) 1162.851
InChI Key FMQURVHYTBGYSQ-UHFFFAOYSA-H
Synonym 8,8'-[carbonylbis(imino-3,1-phenylenecarbonylimino)]bis-1,3,5-naphthalene-trisulphonic acid, hexasodium salt
PubChem CID 101921976
IUPAC Name hexasodium;3-[[N-[3-[N-(4,8-disulfo-6-sulfonatonaphthalen-1-yl)-C-oxidocarbonimidoyl]phenyl]-C-oxidocarbonimidoyl]amino]-N-(8-sulfo-4,6-disulfonatonaphthalen-1-yl)benzenecarboximidate
SMILES C1=CC(=CC(=C1)NC(=NC2=CC=CC(=C2)C(=NC3=C4C(=CC(=CC4=C(C=C3)S(=O)(=O)O)S(=O)(=O)[O-])S(=O)(=O)O)[O-])[O-])C(=NC5=C6C(=CC(=CC6=C(C=C5)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)O)[O-].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+]

Specifications

Quantity 50 mg
Formula Weight 1162.86
Percent Purity >98%
Chemical Name or Material NF 023
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