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Tocris Bioscience™ ML 162
Inhibits glutathione peroxidase (GPX4); induces ferroptosis
Brand: Tocris Bioscience™ 7821/50
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Description
ML 162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor. It induces ferroptosis in vivo. It is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50 = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).Specifications
| 2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide | |
| 50 mg | |
| C23H22Cl2N2O3S |
| 1035072-16-2 | |
| Glutathione Peroxidase 4/GPX4 | |
| 0.98 |