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Tocris Bioscience™ MK6-83

TRPML channel activator

Brand:  Tocris Bioscience™ 5547/10

Encompass

Product Code. 15726916

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Description

Description

MK6-83 is a TRPML channel activator (EC50 = 110 nM). Also activates F408Δ and F465L TRPML mutants (EC50 values are 0.1 and 1.23 μM respectively). Restores endolysosomal trafficking and zinc homeostasis in lysosomes of mucolipidosis type IV (MLIV) mutant fibroblasts.
Specifications

Specifications

MK6-83
5-Methyl-N-[2-(1-piperidinyl)phenyl]-2-thiophenesulfonamide
Soluble to 100mM in DMSO and to 20mM in ethanol
Bioactive Small Molecule
1062271-24-2
10 mg
Solid
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Research Use Only. Not For Human or Veterinary Use