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MK 386, Tocris Bioscience™

Product Code. 30001016
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Quantity:
1 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent, selective human type 1 5α-reductase inhibitor

Potent and selective human type 1 5α-reductase inhibitor (5αR1, IC50 = 0.9 nM). Exhibits 100-fold selectivity for 5αR1 over 5αR2 (IC50 = 154 nM). Supresses human serum and sebum dihydrotestosterone (DHT) levels in a dose-dependent manner without affecting semen DHT concentrations. Orally active.

Specifications

CAS 158493-17-5
Molecular Formula C28H49NO
Linear Formula C28H49NO
Quantity 1 mg
Synonym MK 386
Solubility Information Soluble to 100mM in DMSO
InChI Key XUTZDXHKQDPUMA-MVJJLJOTSA-N
SMILES CC1CC2C(CCC(=O)N2C)(C3C1C4CCC(C4(CC3)C)C(C)CCCC(C)C)C
IUPAC Name (1R,3aS,3bS,4S,5aR,9aR,9bS,11aR)-4,6,9a,11a-tetramethyl-1-[(2R)-6-methylheptan-2-yl]-2,3,3a,3b,4,5,5a,8,9,9b,10,11-dodecahydro-1H-indeno[5,4-f]quinolin-7-one
Molecular Weight (g/mol) 415.706
PubChem CID 9888107
Formula Weight 415.69
Percent Purity >98%
Physical Form Oil
Chemical Name or Material (4aR,4bS,6aR,7R,9aS,9bS,10S,11aR)-7-[(1R)-1,5-Dimethylhexyl]hexadecahydro-1,4a,6a,10-tetramethyl-2H-
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