missing translation for 'onlineSavingsMsg'
Learn More
  1. Home
  2. Products
  3. Chemicals
  4. Organic compounds
  5. Benzenoids
  6. Benzene and substituted derivatives
  7. Diphenylmethanes
  8. 18014432

Meclizine dihydrochloride, Tocris Bioscience™

Product Code. 18014432
Click to view available options
Quantity:
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Human pregnane X receptor agonist; H1 antagonist

Meclizine dihydrochloride is a human pregnane X receptor (hPXR) agonist; it is a more potent activator of hPXR than rat PXR. Meclizine increases hPXR target gene expression in human hepatocyte primary cultures. It also acts as a histamine H1 receptor antagonist. Meclizine attenuates mitochondrial respiration and increases glycolysis. The product inhibits rotenone-induced cell death in stem cell-derived dopaminergic neuronal culture and confers neuroprotection in models of polyglutamine (polyQ) toxicity.

Specifications

CAS 1104-22-9
Molecular Formula C25H29Cl3N2
Quantity 50 mg
Synonym meclizine dihydrochloride, meclozine dihydrochloride, bonamine, meclizine hydrochloride, postafen, vertizine, taizer, v-cline, 1-4-chlorophenyl phenyl methyl-4-3-methylbenzyl piperazine dihydrochloride, duremesin
InChI Key VCTHNOIYJIXQLV-UHFFFAOYSA-N
SMILES CC1=CC(=CC=C1)CN2CCN(CC2)C(C3=CC=CC=C3)C4=CC=C(C=C4)Cl.Cl.Cl
IUPAC Name 1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine;dihydrochloride
Molecular Weight (g/mol) 463.871
PubChem CID 64713
Formula Weight 463.87
Percent Purity >99%
Chemical Name or Material Meclizine dihydrochloride
Show More Show Less
Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.