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Tocris Bioscience™ Klotho-derived peptide 1

TGF-β receptor 2 (TβR2) binding peptide; disrupts the TGF-β/TβR2 interaction

Brand:  Tocris Bioscience™ 7830/1

Product Code. 18023882

  • 2025.00 NOK / 1mg

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Description

Description

Klotho-derived peptide 1 (KP1) is a peptide that binds to TGF-β receptor 2 (TβR2) (Kd = 1.4 μM). It inhibits TGF-β signaling by blocking TGF-β/TβR2 interaction. In mouse models of renal fibrosis, intravenous injection of KP1 results in its specific accumulation in the injured kidneys. It suppresses TGF-β signaling, repressing fibroblast activation and ameliorates kidney fibrosis in vivo.
Specifications

Specifications

9365
Store at -20°C
M.W. (Observed): 3228.48
95%
EC 3.2.1, EC 3.2.1.31, KL, klotho, TGFB2, TGFbeta, TGFbeta 2
1 mg
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