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  7. Thermo Scientific Chemicals Ketoconazole, 98%

Thermo Scientific Chemicals Ketoconazole, 98%

Product Code. 15515156
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Quantity:
1 g
5 g
25 g
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Ketoconazole, CAS # 65277-42-1, is a synthetic, broad-spectrum antifungal agent with the ability to inhibit a variety of fungal infections.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description
• Ketoconazole is an imidazole antifungal agent
• It functions by inhibiting synthesis of ergosterol, which is the fungal equivalent of cholesterol
Applications
• Ketoconazole shows fungicide activity against a variety of yeast infections
• It is an inhibitor of CYP3A4, which is necessary for the conversion of lanosterol to ergosterol
• It increases fungal cellular permeability
• It also inhibits endogenous respiration by disrupting membrane phospholipids
• Ketoconazole can also inhibit the synthesis of thromboxane and sterols such as aldosterone, cortisol, and testosterone
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 65277-42-1
Molecular Formula C26H28Cl2N4O4
Molecular Weight (g/mol) 531.44
InChI Key XMAYWYJOQHXEEK-SIULDFEJSA-N
Synonym ketoconazole
PubChem CID 76973198
IUPAC Name 2,2,2-trideuterio-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
SMILES CC(=O)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=CN=C4)C5=C(C=C(C=C5)Cl)Cl

Specifications

Melting Point 148.0°C to 150.0°C
Loss on Drying 0.5% max. (80°C, 4 h) (vacuum)
Infrared Spectrum Authentic
Assay Percent Range 97.5% min. (HPLC)
Quantity 5 g
Solubility Information Solubility in water: almost insoluble. Other solubilities: soluble in methanol,less soluble in ethanol,slightly soluble in dichloromethane or chloroform
Formula Weight 531.44
Percent Purity 98%
Chemical Name or Material Ketoconazole

Safety and Handling

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Product Identifier
  • Ketoconazole
 Signal Word
  • Danger
 Hazard Category
  • Acute toxicity Category 3
  • LONG-TERM AQUATIC HAZARD Chronic 1
  • ACUTE AQUATIC Acute 1
  • Reproductive toxicity Category 1B
  • Specific target organ toxicity after repeated exposure Category 2
 Hazard Statement
  • H400-Very toxic to aquatic life.
  • H410-Very toxic to aquatic life with long lasting effects.
  • H360F-May damage fertility.
  • H373-May cause damage to organs.
  • H301-Toxic if swallowed.
 Precautionary Statement
  • P201-Obtain special instructions before use.
  • P264-Wash thoroughly after handling.
  • P270-Do not eat, drink or smoke when using this product.
  • P273-Avoid release to the environment.
  • P280-Wear protective gloves/protective clothing/eye protection/face protection.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only

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