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Tocris Bioscience™ (+)-JQ1 maleimide
JQ1-maleimide functionalized probe; induces proteasomal degradation of BRD4
Brand: Tocris Bioscience™
3011.02 NOK valid until 2024-12-16
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Description
(+)-JQ1 maleimide is a probe that comprises a cysteine-reactive maleimide connected to the BRD4 ligand, JQ1, via a PEG2 linker. It can be used in the COFFEE method (COvalent Functionalization Followed by E3 Electroporation) in which (+)-JQ1 maleimide is covalently attached to VHL followed by electroporation into live cells. The E3 ligase forms a complex with BRD4 intracellularly and induces its degradation.Specifications
| (S)-N-(2-(2-(2-(2-(4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)ethoxy)ethoxy)ethyl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide | |
| Active Degraders | |
| 95% |
| 10 mg | |
| C35H42ClN7O6S |