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Tocris Bioscience™ IRAK3 Degrader 23

IRAK3 PROTAC™ Degrader

Brand:  Tocris Bioscience™ 7983/5

Product Code. 18784454

  • 4015.00 NOK / 5mg

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Description

Description

IRAK3 Degrader 23 is a potent and selective IRAK3 PROTAC™ Degrader (DC50 = 2 nM; Dmax = 98% in THP1 cells and primary macrophages), requires CRBN and IRAK3 binding for Degrader activity. Also inhibits CDK11, CDK8, TRKC and GSG2 (IC50 values are 16 nM, 36 nM, 100 nM and 110 nM respectively).PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.
Specifications

Specifications

2-(2,6-Dioxo-3-piperidyl)-5-[4-[2-[1-[4-[4-[cis-4-[(5-isopropylpyrrolo[2,1-f][1,2,4]triazin-4-yl)amino]cyclohexyl]-piperazin-1-yl]-4-oxo-butanoyl]-4-piperidyl]ethyl]piperazin-1-yl]-isoindoline-1,3-dione
5 mg
C47H63N11O6
2712600-00-3
Active Degraders
0.98
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