Infectious Mononucleosis Test using Latex Agglutination

Description

Carry out specific detection of infectious mononucleosis heterophile antibody with Thermo Scientific™ Oxoid™ Infectious Mononucleosis Kit. This latex agglutination kit is designed to deliver simple, specific and rapid detection of infectious mononucleosis (IM) heterophile antibody.

The latex particles used in the kit are sensitized with bovine red cell mononucleosis antigen. Since bovine red cells, unlike sheep or horse red cells, do not contain antigens that interact with non-IM agglutinins, there is no need to perform differential absorption to verify the specificity of the test results.

Infectious mononucleosis (glandular fever) is an acute infectious disease caused by the Epstein-Barr virus and primarily affects lymphoid tissue. It is characterized by the appearance of enlarged and often tender lymph nodes, enlarged spleen and abnormal lymphocytes in the blood.

Use this rapid, simple and semi-quantitative test to aid the diagnosis of infectious mononucleosis. The presence of infectious mononucleosis antibody in serum or plasma at detectable levels will interact with the sensitized particles to produce visible aggregation, which is a positive result. When agglutination is observed, a diagnosis of IM is highly probable.

• Rapid—results in two minutes
• Simple—easy to implement
• Visual—easy-to-read results
• Specific—improved specificity due to use of bovine source
• Used for qualitative or semi-quantitative testing

Infectious mononucleosis is an acute infectious disease caused by the Epstein-Barr virus. Patients usually, but not always, develop a transient heterophile antibody response. The IM heterophile antibodies appear, especially during acute illness, in about 80 to 90% of adolescents and young adults with classical IM¹. The IM antibody is detected in a smaller number of young children with the classical disease. Since the majority of young children do not develop the full-scale syndrome in the course of primary infection, they should, in general, not be expected to develop IM heterophile antibodies. The IM antibody titre usually achieves significant diagnostic levels by the end of the first week of illness.

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