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Tocris Bioscience™ Ibrutinib
Potent and selective BTK inhibitor (IC50= 0.5 nM)
Brand: Tocris Bioscience™ 6813/10
1677.71 NOK valid until 2024-12-16
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Description
Ibrutinib is a potent and selective BTK inhibitor (IC50= 0.5 nM). Selective for BTK against a screening panel of kinase enzymes. Inhibits autophosphorylation of BTK, phosphorylation of PLCγ, and phosphorylation of ERK (IC50 of 11 nM, 29 nM and 13 nM, respectively). Also inhibits ErbB4 (IC50 = 0.25-3.4 nM). Induces cytotoxicity of chronic lymphocytic leukemia (CLL) cells. Reduces clinical arthritis scores in a mouse model.Specifications
| 1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one | |
| Agammaglobulinaemia tyrosine kinase, AGMX1, ATKIMD1, B-cell progenitor kinase, BPK, Bruton agammaglobulinemia tyrosine kinase, Bruton tyrosine kinase, dominant-negative kinase-deficient Brutons tyrosine kinase, tyrosine-protein kinase | |
| C25H24N6O2 | |
| 98% |
| 936563-96-1 | |
| 10 mg | |
| 440.5 |