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  7. Hydroxyurea, 98%, Thermo Scientific Chemicals

Hydroxyurea, 98%, Thermo Scientific Chemicals

Product Code. 10646162
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Quantity:
5 g
25 g
100 g
Packaging:
Glass bottle

Description

Hydroxyurea, 98%, CAS # 127-07-1, is a compound with antineoplastic, immunomodulatory, radical scavenger, and antimitotic activities. It shows inhibitory activity against nucleic acid synthesis.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Hydroxyurea is a member of the class of urea that shows antineoplastic, immunomodulatory, radical scavenger, and antimitotic activities.

• It has inhibitory activity against nucleic acid synthesis.

• It also inhibits ribonucleoside diphosphate reductase, an enzyme necessary to convert ribonucleoside diphosphate into deoxyribonucleoside diphosphate, preventing cells from leaving the G1/S phase of the cell cycle

Applications

• Hydroxyurea has an anti-retroviral activity, inhibiting human immunodeficiency virus type 1 (HIV-1) DNA synthesis in peripheral blood lymphocytes, decreasing the amount of intracellular deoxynucleotides

• This compound also has a radio sensitizing activity, maintaining cells in the radiation-sensitive G1 cell cycle phase and, consequently, interfering with DNA repair

• It has been used for cell cycle synchronization in human breast carcinoma cells

• This compound presents inhibitory activity in cell adhesion and motility assay in ccRCC Caki (HTB-47) and CD9 knockdown cells

TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 127-07-1
Molecular Formula CH4N2O2
Molecular Weight (g/mol) 76.04
MDL Number MFCD00007943
InChI Key VSNHCAURESNICA-UHFFFAOYSA-N
Synonym hydroxycarbamide, n-hydroxyurea, hydrea, 1-hydroxyurea, oxyurea, carbamoyl oxime, biosupressin, hydroxycarbamine, onco-carbide, carbamohydroxamic acid
PubChem CID 3657
ChEBI CHEBI:44423
IUPAC Name hydroxyurea
SMILES C(=O)(N)NO

Specifications

Melting Point 142°C to 146°C
Color White
Loss on Drying 1% max. (1 g, 60°C) (< 0.7 kPa)
Infrared Spectrum Authentic
Assay Percent Range 97.5% min. (on dried substance) (Iodometry)
Packaging Glass bottle
Linear Formula HONHCONH2
Quantity 25 g
Beilstein 03, 95
Merck Index 15, 4888
Solubility Information Solubility in water: freely soluble. Other solubilities: freely soluble in hot alcohol
Formula Weight 76.04
Percent Purity 98%
Physical Form Crystalline Powder
Chemical Name or Material Hydroxyurea
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Safety and Handling

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Product Identifier
  • Hydroxyurea
 Signal Word
  • Danger
 Hazard Category
  • Germ cell mutagenicity Category 1B
  • Reproductive toxicity Category 1A
 Hazard Statement
  • H360D-May damage the unborn child.
  • H340-May cause genetic defects.
 Precautionary Statement
  • P201-Obtain special instructions before use.
  • P308+P313-IF exposed or concerned: Get medical advice/attention.

RUO – Research Use Only

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