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Gibco™ Human SCF Recombinant Protein, PeproTech®
Recombinant Protein
810.00 NOK - 24250.00 NOK
Specifications
Accession Number | P21583 |
---|---|
For Use With (Application) | ELISA, Functional Assay, Western Blot |
Formulation | protein with no preservative |
Gene ID (Entrez) | 4254 |
Molecular Weight (g/mol) | 18.4 kDa |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17840423
|
Gibco™
300-07-100UG |
100 μg |
5240.00 NOK
100µg |
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17810333
|
Gibco™
300-07-10UG |
10 μg |
1972.00 NOK
10µg |
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17830423
|
Gibco™
300-07-1MG |
1 mg |
24250.00 NOK
1mg |
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17861393
|
Gibco™
300-07-250UG |
250 μg |
8500.00 NOK
250µg |
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17841593
|
Gibco™
300-07-2UG |
2 μg |
810.00 NOK
2µg |
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17830823
|
Gibco™
300-07-500UG |
500 μg |
14610.00 NOK
500µg |
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17830993
|
Gibco™
300-07-50UG |
50 μg |
3105.00 NOK
50µg |
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Description
Recombinant Human SCF is an 18.4 kDa polypeptide containing 165 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.Specifications
P21583 | |
protein with no preservative | |
18.4 kDa | |
E. coli | |
<1 EU/ μg | |
SCF | |
The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg | |
Recombinant | |
-20°C | |
Lyophilized |
ELISA, Functional Assay, Western Blot | |
4254 | |
Human SCF | |
RUO | |
710-712; blz; c-Kit ligand; Clo; cloud gray; Con; contrasted; CSF; DCUA; DFNA69; DKFZp686F2250; familial progressive hyperpigmentation 2; FPH2; FPHH; Gb; grizzle-belly; hematopoietic growth factor KL; H-SCF; Kit ligand; Kitl; Kitlg; kit-ligand; KL-1; Mast cell growth factor; MGF; M-SCF; Processed kit ligand; SCF; SF; SHEP7; sKITLG; Sl; SLF; Soluble KIT ligand; Steel factor; steel factor/kit ligand; stem cell factor; stem cell factor KL-1; stem cell factor, CSF | |
KITLG | |
Unconjugated | |
MEGICRNRVT NNVKDVTKLV ANLPKDYMIT LKYVPGMDVL PSHCWISEMV VQLSDSLTDL LDKFSNISEG LSNYSIIDKL VNIVDDLVEC VKENSSKDLK KSFKSPEPRL FTPEEFFRIF NRSIDAFKDF VVASETSDCV VSSTLSPEKD SRVSVTKPFM LPPVA | |
E. coli | |
≥ 98% by SDS-PAGE gel and HPLC analyses. |
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