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Invitrogen™ Human PKR Synthetic Peptide
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Quantity:
50 μg
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50µg
Description
PKR Synthetic Peptide, PEP-0417, from Invitrogen.
EIF2AK2 (PKR) is one of 4 kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. EIF2AK2 plays a key role in antiviral defense mediated through its direct activation by double-stranded RNA produced by viral infection. PKR plays a key role in IFN induced-innate antiviral response, virus-induced apoptosis, cell growth & differentiation. PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling pathway. Upon viral infection, it functions as a dual protein, sequentially activating both cell survival & cell death pathways using kinase independent and dependent strategies. PRKR regulates multiple pathways which include NF-kappaB activation, p53, p38, & PDGF signaling pathway. PKR has been implicated in tumor suppression & malignancy. To evade the antiviral effects of PKR, viruses have evolved multiple mechanisms, such as the inhibition of PKR by the non-structural protein (NS1) of the influenza virus. More recently, PKR has been implicated in several neurodegenerative diseases including Alzheimer, Huntington, and amyotrophic lateral sclerosis.

Specifications
Specifications
Gene ID (Entrez) | 5610 |
Species | Human |
Purification Method | purified |
Accession Number | P19525 |
Common Name | Human PKR |
Concentration | 200 μg/mL |
Content And Storage | -20°C |
Description | Synthetic Peptide |
Format | Liquid |
Formulation | PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2 |
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