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Gibco™ Human PDGF-AA Recombinant Protein, PeproTech®

Recombinant Protein

836.00 NOK - 40420.00 NOK

Specifications

Accession Number P04085
For Use With (Application) ELISA, Functional Assay, Western Blot
Formulation protein with no preservative
Gene ID (Entrez) 5154
Molecular Weight (g/mol) 28.5 kDa
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Products 7
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17870473
View Documents Promotion Details
Gibco™
100-13A-100UG
100 μg
8080.00 NOK
100µg
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17810323
View Documents Promotion Details
Gibco™
100-13A-10UG
10 μg
2035.00 NOK
10µg
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17891353
View Documents
Gibco™
100-13A-1MG
1 mg
40420.00 NOK
1mg
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17830323
View Documents Promotion Details
Gibco™
100-13A-250UG
250 μg
14190.00 NOK
250µg
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17871253
missing translation for 'viewDocuments' Detalles de la promoción
Gibco™
100-13A-2UG
2 μg
836.00 NOK
2µg
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17870293
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Gibco™
100-13A-500UG
500 μg
24310.00 NOK
500µg
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17821773
missing translation for 'viewDocuments' Detalles de la promoción
Gibco™
100-13A-50UG
50 μg
4825.00 NOK
50µg
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Descripción

Descripción

Platelet-derived growth factor (PDGF) was discovered as a major mitogenic factor present in serum but absent from plasma. It was found to be secreted from the alpha -granules of platelets activated during the coagulation of blood to form serum. Subsequent studies have demonstrated that PDGF is not one molecule but three, each a dimeric combination of two distinct but structurally related peptide chains designated A and B. The dimeric isoforms PDGF-AA, AB and BB are differentially expressed in various cell types and their effects are mediated through two distinct receptors, termed alpha and beta. Differences exist in isoform binding to each receptor. In general, PDGF isoforms are potent mitogens for connective tissue cells, including dermal fibroblasts, glial cells, arterial smooth muscle cells and some epithelial and endothelial cells. In addition to its activity as a mitogen, PDGF is chemotactic for fibroblasts, smooth muscle cells, neutrophils and mononuclear cells. Other reported activities for PDGF include stimulation of granule release by neutrophils and monocytes, facilitation of steroid synthesis by Leydig cells, stimulation of neutrophil phagocytosis, inhibition of natural killer (NK) cell activity, stimulation of collagen synthesis, modulation of thrombospondin expression and secretion, stimulation of collagenase activity and secretion, induction of contraction of rat aorta strips in vitro, and transient induction of T cell IL-2 secretion accompanied by a down-regulation of IL-4 and IFN-gamma production, temporary effects that may allow clonal expansion of antigen-activated B and T helper lymphocytes prior to differentiation. PDGF also appears to be ubiquitous in neurons throughout the CNS, where it is suggested to play an important role in neuron survival and regeneration, and in mediation of glial cell proliferation and differentiation.
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Gibco™ Human PDGF-AA Recombinant Protein, PeproTech®

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