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Gibco™ Human OAT1 (G) SLC Transporter Cells
HEK293 cells that transiently overexpress the OAT1 solute carrier (SLC) transport protein
Brand: Gibco™ GM1103G
This item is not returnable.
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Description
- TRANSiPORT Human OAT1 (G) SLC Transporter Cells are HEK293 cells that transiently overexpress the OAT1 solute carrier (SLC) transport protein. Solute carriers are a super-family of membrane transporters that can affect pharmacokinetics and drug exposure by governing the transport of solutes in and out of cells. The OAT1 SLC transporter protein is found in kidney proximal tubule cells.
- Assess potential for transporter-mediated drug metabolism
- Easy to use format
- Obtain high quality results with a large signal-to-noise ratio
- Cell-based assays can be performed using radioisotope-labeled compounds, fluorescence-labeled compounds, or non-labeled compounds. The amount of substrate transported into the cells can be measured directly using a liquid scintillation counter, fluorescence plate reader, or LC-MS/MS, thereby allowing direct evaluation of SLC transporter activity.
- Mock HEK293 cells (Cat. No. GM1101G) that do not overexpress the SLC transporter are available for use as a negative experimental control. Some compounds may demonstrate high background levels of transport due to the presence of endogenous transporters or non-specific binding.
- The convenient product format enables data generation in 2 days from thawing of the cells to final results.
Specifications
| Store in liquid nitrogen vapor phase. | |
| Mammalian Cell Culture | |
| 8-10 x 106 cells |
| 293 (HEK) | |
| Human | |
| SLC Transporter Cell |