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Gibco™ Human IL-15 Recombinant Protein, PeproTech®
Recombinant Protein
836.00 NOK - 40420.00 NOK
Specifications
Accession Number | P40933 |
---|---|
For Use With (Application) | ELISA, Functional Assay, Western Blot |
Formulation | protein with no preservative |
Gene ID (Entrez) | 3600 |
Molecular Weight (g/mol) | 12.9 kDa |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17811783
|
Gibco™
200-15-100UG |
100 ÎĽg |
8080.00 NOK
100µg |
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17851303
|
Gibco™
200-15-10UG |
10 ÎĽg |
2035.00 NOK
10µg |
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17861083
|
Gibco™
200-15-1MG |
1 mg |
40420.00 NOK
1mg |
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17830223
|
Gibco™
200-15-250UG |
250 ÎĽg |
14190.00 NOK
250µg |
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17830603
|
Gibco™
200-15-2UG |
2 ÎĽg |
836.00 NOK
2µg |
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17871083
|
Gibco™
200-15-500UG |
500 ÎĽg |
24310.00 NOK
500µg |
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17850223
|
Gibco™
200-15-50UG |
50 ÎĽg |
4825.00 NOK
50µg |
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Description
Recombinant Human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.Specifications
P40933 | |
protein with no preservative | |
12.9 kDa | |
E. coli | |
<1 EU/ ÎĽg | |
IL-15 | |
The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 10^6 units/mg | |
Recombinant | |
-20°C | |
Lyophilized |
ELISA, Functional Assay, Western Blot | |
3600 | |
Human IL-15 | |
RUO | |
AI503618; il 15; Il15; IL-15; ILN; Interleukin; interleukin 15; Interleukin15; interleukin-15; MGC9721; M-IL-15 | |
IL15 | |
Unconjugated | |
MNWVNVISDL KKIEDLIQSM HIDATLYTES DVHPSCKVTA MKCFLLELQV ISLESGDASI HDTVENLIIL ANNSLSSNGN VTESGCKECE ELEEKNIKEF LQSFVHIVQM FINTS | |
E. coli | |
≥ 98% by SDS-PAGE gel and HPLC analyses. |
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Product Title
Gibco™ Human IL-15 Recombinant Protein, PeproTech®