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Gibco™ Human IL-15 Recombinant Protein, PeproTech®

Recombinant Protein

836.00 NOK - 40420.00 NOK

Specifications

Accession Number P40933
For Use With (Application) ELISA, Functional Assay, Western Blot
Formulation protein with no preservative
Gene ID (Entrez) 3600
Molecular Weight (g/mol) 12.9 kDa
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Products 7
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17811783
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Gibco™
200-15-100UG
100 ÎĽg
8080.00 NOK
100µg
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17851303
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Gibco™
200-15-10UG
10 ÎĽg
2035.00 NOK
10µg
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17861083
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Gibco™
200-15-1MG
1 mg
40420.00 NOK
1mg
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17830223
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Gibco™
200-15-250UG
250 ÎĽg
14190.00 NOK
250µg
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17830603
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Gibco™
200-15-2UG
2 ÎĽg
836.00 NOK
2µg
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17871083
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Gibco™
200-15-500UG
500 ÎĽg
24310.00 NOK
500µg
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17850223
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Gibco™
200-15-50UG
50 ÎĽg
4825.00 NOK
50µg
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Description

Description

Recombinant Human IL-15 is a 12.9 kDa protein consisting of 115 amino acid residues. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation. IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2. IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis. IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules. As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases. Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases. Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.
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