missing translation for 'onlineSavingsMsg'
Learn More

Invitrogen™ Human Estrogen Receptor beta (aa 55-70) Synthetic Peptide

Synthetic Peptide

Brand:  Invitrogen™ PEP011

Product Code. 11548881

  • 1418.00 NOK / 50µg

Please to purchase this item. Need a web account? Register with us today!

Explore more special offers
This item is not returnable. View return policy

Description

Description

Human Estrogen Receptor B (ERb) (residues 55-70) Synthetic Peptide, PEP-011, from Invitrogen.

Estrogen Receptor beta (ER beta, NR3A2) protein is approximately 55kD, though multiple isoforms ranging from 36-59kD have been described. Human ER beta was initially cloned and characterized from testis. Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor, that when bound to estrogen hormone, induces a conformational change that allows dimerization and binding to estrogen response elements (ERE) in DNA. When bound to EREs, ER can positively or negatively regulate gene transcription through the recruitment of coactivator or corepressor proteins. There are two different forms of the estrogen receptor, alpha and beta, encoded by separate genes (ESR1 and ESR2, respectively). Estrogen receptor beta (ER beta) binds estrogens with an affinity similar to that of estrogen receptor alpha. Some ER beta isoforms dominantly inhibit the activity of estrogen receptor alpha in reproductive tissues. ER beta is found widely in many tissues throughout the body and can act as a potent tumor suppressor, playing a crucial role in many cancer types such as prostate cancer, autism spectrum disorder, medullary thyroid carcinoma, De Quervain Disease and risk of cardiovascular disease.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

2100
purified
Human Estrogen Receptor beta (aa 55-70)
-20°C. Avoid freeze-thaw cycles.
Lyophilized
Control
Lyophilized
Peptide
RUO - research use only
Human
Q92731
0.5 mg/mL
Synthetic Peptide
peptide with no preservative
ESR2
No preservative
50 μg
A - E - P - Q - K - S - P - W - C - E - A - R - S - L - E - H
Product Suggestions

Product Suggestions

Videos
SDS
Documents

Documents

One moment while we fetch your results.
Certificates
Special Offers

Special Offers

Product Content Correction

Your input is important to us. Please complete this form to provide feedback related to the content on this product.

Product Title
Invitrogen™ Human Estrogen Receptor beta (aa 55-70) Synthetic Peptide > 50 μg; Unlabeled

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.

Thank You! Your feedback has been submitted. Fisher Scientific is always working to improve our content for you. We appreciate your feedback.