Invitrogen™ Human BACE2 (aa 441-457) Synthetic Peptide

Description

Human BACE2 (residues 441-457) Synthetic Peptide, PEP-166, from Invitrogen.

BACE2 or Beta Secretase 2 is responsible for the proteolytic processing of the amyloid precursor protein (APP). BACE2 cleaves APP between residues 690 and 691. This cleavage leads to the generation and extracellular release of beta-cleaved soluble APP. BACE2 is also know to cleave APP between residues 671 and 672. Accumulation of APP is a signature of Alzheimer disease and frequent complication of adult Down syndrome patients. PEP-166 is an 18 amino acid synthetic peptide whose sequence is derived from human BACE2 protein. The sequence of this peptide is (amino to carboxy terminus): V (441)-S-E-I-S-G-P-F-S-T-E-D-I-A-S-N-C (457)This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and human BACE2, catalog &Num; PA1-753. Using a solution of peptide of equal volume and concentration to the corresponding antibody will yield a large molar excess of peptide (∽70-fold) for competitive inhibition of antibody-protein binding reactions.Reconstitute with 0.1 mL of distilled water.