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Invitrogen™ Human AMBRA1 Synthetic Peptide Product Code.: 15348820

Invitrogen™ Human AMBRA1 Synthetic Peptide

Product Code. 15348820
50 μg, 50µg
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Quantity:
50 μg
Unit Size:
50µg
This item is not returnable. View return policy

Product Code. 15348820

Brand: Invitrogen™ PEP0632

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This item is not returnable. View return policy

Synthetic Peptide

Ambra1 Synthetic Peptide, PEP-0632, from Invitrogen.

Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. Beclin-1, a principal regulator of autophagosome formation, is in turn regulated by Ambra1. Ambra1 associates with Beclin-1 through a region near its center as determined by yeast two-hybrid assay. Null mutations in this gene in mice resulted in embryonic lethality with severe neural tube defects associated with autophagy impairment, accumulation of ubiquitinated proteins, unbalanced cell proliferation and excessive apoptotic death. Furthermore, down-regulation of Ambra1 in cultured cells though RNA interference decreased the level of rapamycin- and nutrient starvation-induced autophagy. Multiple isoforms of Ambra1 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Gene ID (Entrez) 55626
Species Human
Purification Method purified
Accession Number Q9C0C7
Common Name Human AMBRA1
Concentration 200 μg/mL
Content And Storage -20°C
Description Synthetic Peptide
Format Liquid
Formulation PBS with 0.1% BSA and 0.02% sodium azide; pH 7.2
For Use With (Application) Blocking Assay, Control
Gene Symbol AMBRA1
Lyophilized No
Preservative 0.02% sodium azide
Product Type Peptide
Quantity 50 μg
Regulatory Status RUO - research use only
Storage Buffer PBS
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