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Invitrogen™ Fluorescein-PGC1a Coactivator Peptide, 100 μM
1712.00 NOK - 8310.00 NOK
Specifications
| Content And Storage | Store in freezer (-5 to -30°C). |
|---|---|
| Label Type | Classic Dyes |
| Shipping Condition | Dry Ice |
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|
10746983
|
Invitrogen™
PV4421 |
100 μL |
1712.00 NOK
Each |
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|
10443483
|
Invitrogen™
PV4422 |
1 mL |
8310.00 NOK
1mL |
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Description
Ligand binding to nuclear receptors causes conformational changes in the receptor, resulting in a cascade of events, including dissociation of repressor proteins, association of coactivator proteins, and assembly of pol II and other transcriptional factors for activation of target genes. TR-FRET based assays can be developed using the LanthaScreen™ panel of fluorescein-labeled coregulator peptides to investigate conformational changes of nuclear receptors upon ligand binding, either by determining the affinity of ligand-bound receptor for different coregulator peptides, or by identifying additional agonists or antagonists via displacement or recruitment of a specific coregulator peptide.
In the LanthaScreen™ TR-FRET RXR beta Coactivator Assay, a terbium (Tb)-labeled anti-GST antibody is used to indirectly label GSTtagged RXR beta protein. An agonist (9-cis Retinoic Acid) added to the receptor which, upon ligand binding, causes a conformational change resulting in recruitment of the Fl-D22 coactivator peptide. The binding of the fluorescent coregulator peptide to RXR beta causes an increase in the TR-FRET emission ratio.
Specifications
| Store in freezer (-5 to -30°C). | |
| Classic Dyes | |
| Dry Ice |
For Research Use Only. Not for use in diagnostic procedures.
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