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Thermo Scientific™ EZ-Link™ TFP Ester-PEG12-DBCO
A heterobifunctional crosslinker that contains an amine reactive tetrafluorophenyl (TFP) and a dibenzylcyclooctyne (DBCO) with a water solubilizing long PEG12 spacer in between. Use to label any primary amine containing molecule such as a protein to biomolecule with a distantly attached DBCO group.
Brand: Thermo Scientific™ C20040
1620.08 NOK valid until 2025-03-29
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Description
- A heterobifunctional crosslinker that contains an amine reactive tetrafluorophenyl (TFP) and a dibenzylcyclooctyne (DBCO) with a water solubilizing long PEG12 spacer in between the two groups
- This crosslinker can be used to label any primary amine containing molecule such as a protein to biomolecule with a distantly attached DBCO group
- Once a protein or (bio)molecule is DBCO labeled, it can undergo a copper-free azide-alkyne cycloaddition reaction to form a stable triazole linkage with an azide labeled coupling partner
- Can be used to create diverse conjugates with the biorthogonal coupling between an alkyne and azide (supplied separately)
- The coupling or crosslinking procedure is typically done in two steps:
- First, a protein or amine containing molecule is labeled with a DBCO group and excess crosslinker is removed
- Second, an azide containing moiety (prepared independently) is introduced into the same system as the DBCO moiety
- Labeling occurs under biological conditions without the introduction of any additional reagents such as a copper catalyst
- Reagent readily dissolves in water-miscible solvents for dilution into aqueous reaction mixtures
- TFP esters are more hydrolytically stable than NHS esters
Specifications
| Amine-Azide | |
| TFP Ester-PEG12-DBCO | |
| Yes | |
| Upon receipt store desiccated at -20°C. | |
| Wet Ice | |
| Chemical Labeling | |
| TFP Ester, DBCO | |
| Liquid | |
| DMF, DMSO | |
| No |
| No | |
| 1067.12 | |
| 46.3 Å | |
| Not determined | |
| EZ-Link™ | |
| Heterobifunctional | |
| Long (>30 Å) | |
| 25 mg | |
| Standard | |
| Crosslinker |
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Product Title
Thermo Scientific™ EZ-Link™ TFP Ester-PEG12-DBCO > 25 mg
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