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Eurofins DiscoverX EGFR (L858R) Protein, Active

Product Code. 17340454
10 μg, 10µg
Encompass_Preferred
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Quantity:
10 μg
250 μg
Unit Size:
10µg
250µg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Active, N-terminal GST-tagged, recombinant human EGF Receptor, amino acids 696-end containing the mutation L858R, for use in Enzyme Assays.

Receptors that are tyrosine protein kinases include those receptors for epidermal growth factor (EGF), platelet-derived growth factor (PDGF), insulin, and certain lymphokines. Receptor tyrosine kinases are cell surface transmembrane proteins responsible for intracellular signal transduction. They are expressed in many cell types and, after activation by growth factor binding, trigger a series of intracellular pathways leading to a wide variety of responses; e.g. differentiation, proliferation, migration and invasion, angiogenesis, survival. EGF receptor agonism may facilitate wound healing, enhance viral infections, topical inflammation and asthma as well as tumor cell proliferation and metastasis.

GenBank X00588

Specifications

Formulation mg/mL of enzyme in 50 mM Tris/HCl pH 7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 1 mM benzamidine, 0.2 mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution.
Molecular Weight (g/mol) 85.8 kDa
Quantity 10 μg
Species Human
Recombinant Recombinant
Protein Tag N-terminal GST
Expression System Recombinant enzyme expressed in Sf21 insect cells
Protein Form Truncated
Purity or Quality Grade ≥43%
Protein EGFR (L858R), active
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Eurofins DiscoverX EGFR (L858R) Protein, Active

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