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E-64, Thermo Scientific Chemicals
Selective and irreversible cysteine protease inhibitor
1742.40 NOK - 7074.00 NOK
Chemical Identifiers
CAS | 66701-25-5 |
---|---|
Molecular Formula | C15H27N5O5 |
Molecular Weight (g/mol) | 357.41 |
MDL Number | MFCD00080261,MFCD00080261 |
InChI Key | LTLYEAJONXGNFG-HBNTYKKESA-N |
Synonym | d09fgq, l-3-trans-carboxy-oxiran-2-carbonyl-leu-agmatin, trans-epoxysuccinyl-leucylamido-4-guanidino butane, 3-1-4-carbamimidamidobutyl carbamoyl-3-methylbutyl carbamoyl oxirane-2-carboxylic acid, 3-1-4-diaminomethylideneamino butylamino-4-methyl-1-oxopentan-2-yl carbamoyl oxirane-2-carboxylic acid |
PubChem CID | 4641099 |
IUPAC Name | 3-[[1-[4-(diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid |
SMILES | CC(C)C[C@H](NC(=O)[C@@H]1O[C@H]1C(O)=O)C(=O)NCCCCN=C(N)N |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15445229
|
Thermo Scientific Alfa Aesar
J62933.#0 |
5 mg |
1742.40 NOK
5mg |
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15455229
|
Thermo Scientific Alfa Aesar
J62933.MB |
25 mg |
7074.00 NOK
25mg |
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Description
It is used as a broad spectrum cysteine proteinase and calpain activation inhibitor. Additionally, Prevotella intermediate studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S. E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
ApplicationsIt is used as a broad spectrum cysteine proteinase and calpain activation inhibitor. Additionally, Prevotella intermediate studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S. E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained
Solubility
Soluble in DMSO (25mg/ml), or water (20mg/ml)
Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong acids, strong bases.
Chemical Identifiers
66701-25-5 | |
357.41 | |
LTLYEAJONXGNFG-HBNTYKKESA-N | |
4641099 | |
CC(C)C[C@H](NC(=O)[C@@H]1O[C@H]1C(O)=O)C(=O)NCCCCN=C(N)N |
C15H27N5O5 | |
MFCD00080261,MFCD00080261 | |
d09fgq, l-3-trans-carboxy-oxiran-2-carbonyl-leu-agmatin, trans-epoxysuccinyl-leucylamido-4-guanidino butane, 3-1-4-carbamimidamidobutyl carbamoyl-3-methylbutyl carbamoyl oxirane-2-carboxylic acid, 3-1-4-diaminomethylideneamino butylamino-4-methyl-1-oxopentan-2-yl carbamoyl oxirane-2-carboxylic acid | |
3-[[1-[4-(diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid |
Specifications
66701-25-5 | |
C15H27N5O5 | |
1405664 | |
d09fgq, l-3-trans-carboxy-oxiran-2-carbonyl-leu-agmatin, trans-epoxysuccinyl-leucylamido-4-guanidino butane, 3-1-4-carbamimidamidobutyl carbamoyl-3-methylbutyl carbamoyl oxirane-2-carboxylic acid, 3-1-4-diaminomethylideneamino butylamino-4-methyl-1-oxopentan-2-yl carbamoyl oxirane-2-carboxylic acid | |
LTLYEAJONXGNFG-HBNTYKKESA-N | |
CC(C)C[C@H](NC(=O)[C@@H]1O[C@H]1C(O)=O)C(=O)NCCCCN=C(N)N | |
357.41 | |
357.4 | |
E-64 |
White | |
MFCD00080261,MFCD00080261 | |
Light sensitive | |
Soluble in DMSO (25mg/ml), or water (20mg/ml) | |
+24° (c=1 in 1N HCl) | |
3-[[1-[4-(diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid | |
4641099 | |
Powder |
Safety and Handling
missing translation for 'rtecsNumber' : RR0390000
missing translation for 'tsca' : No
Recommended Storage : Store at -20°C
RUO – Research Use Only