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Doxycycline hydrochloride
Doxycycline hydrochloride, CAS # 10592-13-9, is the hydrochloride salt form of doxycycline that shows antibacterial and antimalarial activities. | CAS: 10592-13-9 | C22H25ClN2O8 | 480.90 g/mol
Brand: Thermo Scientific Alfa Aesar J60422.06
| Quantity | 5 g |
|---|
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Description
Inhibits angiogenesis and reduces lung metastases by inhibiting matrix metalloproteinases.Doxycycline hydrochloride is an antibiotic used to inhibit matrix metalloproteinases like type 1 collagenase in studies on would healing and tissue remodeling. It shows the broad spectrum antibacterial and antiprotozoan activity. It is often used to treat lyme disease, chronic prostatitis, sinusitis, pelvic inflammatory disease acne, rosacea, and rickettsial infections and prophylaxis of anthrax.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- Doxycycline hydrochloride is a compound that shows antibacterial and antimicrobial activities against several species, including Pseudomonas aeruginosa, Plasmodium falciparum, and Escherichia coli. It is also a bacteriostatic
- It can block the binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis
Application
- It is used to eliminate Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and eliminate Ixodes scapularis ticks
- Doxycycline hydrochloride is also considered to be a broad-spectrum inhibitor used to inhibit matrix metalloproteinases (MMP), such as type 1 collagenase, in wound healing and tissue remodeling studies. Due to this activity, it can inhibit angiogenesis and reduce lung metastases
Chemical Identifiers
| 10592-13-9 | |
| 480.90 | |
| VLUQVUWDECWBTL-UQVCFKGQSA-N | |
| (1S,3Z,4aS,11R,11aR,12S,12aR)-3-[amino(hydroxy)methylidene]-4a,6,7,12-tetrahydroxy-N,N,11-trimethyl-2,4,5-trioxo-1,2,3,4,4a,5,11,11a,12,12a-decahydrotetracen-1-aminium chloride |
| C22H25ClN2O8 | |
| MFCD03427564 | |
| 54706018 | |
| [Cl-].C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H]([NH+](C)C)C(=O)\C(=C(/N)O)C(=O)[C@@]3(O)C(=O)C2=C(O)C2=C(O)C=CC=C12 |
Specifications
| Doxycycline Hydrochloride | |
| 10592-13-9 | |
| Yellow | |
| C22H25ClN2O8 | |
| Soluble in water to 50mg/ml; May require warming. | |
| [Cl-].C[C@@H]1[C@H]2[C@H](O)[C@H]3[C@H]([NH+](C)C)C(=O)\C(=C(/N)O)C(=O)[C@@]3(O)C(=O)C2=C(O)C2=C(O)C=CC=C12 | |
| 480.90 | |
| 480.9 |
| Crystalline Powder | |
| 195°C to 201°C | |
| 5 g | |
| MFCD03427564 | |
| VLUQVUWDECWBTL-UQVCFKGQSA-N | |
| (1S,3Z,4aS,11R,11aR,12S,12aR)-3-[amino(hydroxy)methylidene]-4a,6,7,12-tetrahydroxy-N,N,11-trimethyl-2,4,5-trioxo-1,2,3,4,4a,5,11,11a,12,12a-decahydrotetracen-1-aminium chloride | |
| 54706018 | |
| Doxycycline hydrochloride |
Safety and Handling
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
Supplemental information
- Doxycycline hydrochloride
Signal Word
- Warning
Hazard Category
- Acute toxicity Category 4
- Serious eye damage/eye irritation Category 2
- Skin corrosion/irritation Category 2
- Specific target organ toxicity Category 3
Hazard Statement
- H302-Harmful if swallowed.
- H312-Harmful in contact with skin.
- H315-Causes skin irritation.
- H319-Causes serious eye irritation.
- H332-Harmful if inhaled.
- H335-May cause respiratory irritation.
Precautionary Statement
- P280-Wear protective gloves/protective clothing/eye protection/face protection.
- P301+P330+P331-IF SWALLOWED: rinse mouth. Do NOT induce vomiting.
- P302+P352-IF ON SKIN: Wash with plenty of water/soap.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P312-Call a POISON CENTER/doctor/if you feel unwell.
- P332+P313-If skin irritation occurs: Get medical advice/attention.
- P337+P313-If eye irritation persists: Get medical advice/attention.
Supplemental information
- MIXTURE LIST-Contains : Doxycycline hydrochloride
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Product Title
Doxycycline hydrochloride > 5g
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