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Deoxycholic acid, sodium salt, 99%, extra pure
Deoxycholic acid, sodium salt, CAS # 302-95-4, also designed as sodium deoxycholate, is a biological anionic bile acid detergent that is especially useful for disrupting and dissociating protein interactions. | CAS: 302-95-4 | C24H39NaO4 | 414.56 g/mol
Chemical Identifiers
| CAS | 302-95-4 |
|---|---|
| Molecular Formula | C24H39NaO4 |
| Molecular Weight (g/mol) | 414.56 |
| MDL Number | MFCD00064139 |
| InChI Key | FHHPUSMSKHSNKW-SMOYURAASA-M |
| Synonym | sodium deoxycholate |
| PubChem CID | 91810855 |
| SMILES | [Na+].[H][C@@]12CC[C@H]([C@H](C)CCC([O-])=O)[C@@]1(C)[C@@H](O)C[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@H](O)CC[C@]12C |
Description
This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
General Description
- The deoxycholic acid sodium salt is a bile acid choleretic and anionic detergent that allows the solubilization of fats for intestinal absorption
- The compound is an intermediate in the production of corticosteroids
- In animal models it has been shown that this compound can promote tyrosine phosphorylation of β-catenin and its translocation to the nucleus, promoting the activation of β-catenin signaling
Applications
- Deoxycholic acid is mainly useful for the extraction of membrane receptors, other plasma membrane proteins, nuclei isolation, solubilization and isolation of fats, and some components of biological membranes (in an active state)
- It has been used for chemical applications, mainly for the elution or regeneration of specific types of affinity columns. Furthermore, this compound can be used to prevent non-specific binding in affinity chromatography.
- It has been applied in the preparation of protein extracts for immunoblotting and immunoprecipitation of radiolabeled proteins
- Deoxycholic acid, sodium salt is also recommended for stripping endotoxins
Chemical Identifiers
| 302-95-4 | |
| 414.56 | |
| FHHPUSMSKHSNKW-SMOYURAASA-M | |
| 91810855 |
| C24H39NaO4 | |
| MFCD00064139 | |
| sodium deoxycholate | |
| [Na+].[H][C@@]12CC[C@H]([C@H](C)CCC([O-])=O)[C@@]1(C)[C@@H](O)C[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@H](O)CC[C@]12C |
Specifications
| 302-95-4 | |
| 7.5 to 10 (5% aq. soln.) | |
| Authentic | |
| C24H39NaO4 | |
| 10, III, 1642 | |
| +42° to +46° (20°C, 589nm) (c=2, water) | |
| FHHPUSMSKHSNKW-SMOYURAASA-M | |
| sodium;(4R)-4-[(3R,5R,8R,10S,12S,13R,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoate | |
| 91810855 | |
| 98.5 to 102% (on dry substance) | |
| Crystalline Powder |
| White to Cream | |
| 5% max. (2 g, 105°C, 4 hrs) | |
| 99% | |
| MFCD00064139 | |
| 14, 2899 | |
| sodium deoxycholate | |
| [Na+].[H][C@@]12CC[C@H]([C@H](C)CCC([O-])=O)[C@@]1(C)[C@@H](O)C[C@@]1([H])[C@@]2([H])CC[C@]2([H])C[C@H](O)CC[C@]12C | |
| 414.56 | |
| 414.58 | |
| Extra Pure | |
| Deoxycholic acid, sodium salt |
Safety and Handling
GHS H Statement:
Harmful if swallowed.
May cause respiratory irritation.
GHS P Statement:
Avoid breathing dust/fume/gas/mist/vapors/spray.
IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
WARNING: The information provided on this web site was developed in compliance with European Union (EU) regulations and is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling and use. It is not to be considered as either a warranty or quality specification.
Product Identifier
Signal Word
Hazard Category
Hazard Statement
Precautionary Statement
- Deoxycholic acid, sodium salt
Signal Word
- Warning
Hazard Category
- Acute toxicity Category 4
- Specific target organ toxicity Category 3
Hazard Statement
- H335-May cause respiratory irritation.
- H302-Harmful if swallowed.
Precautionary Statement
- P261-Avoid breathing dust/fume/gas/mist/vapours/spray.
- P264-Wash thoroughly after handling.
- P304+P340-IF INHALED: Remove person to fresh air and keep comfortable for breathing.
- P312-Call a POISON CENTER/doctor/if you feel unwell.
RUO – Research Use Only
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Product Title
Deoxycholic acid, sodium salt, 99%, extra pure