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Demethylasterriquinone B1, Tocris Bioscience™
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Quantity:
5 mg
Description
Selective insulin receptor (IR) activator (EC50 values are 3 - 6 μM for IRTK and 100 μM for IGF1R and EGFR). Increases IR β subunit tyrosine phosphorylation and activation of PI 3-kinase and Akt, but not ERK. Induces glucose uptake in adipocytes and skeletal muscle in vitro, without enhancing vascular proliferation. Binds GAPDH. Also activates Trk by interacting at a site distinct from the neurotrophin-binding site.
Specifications
Specifications
| CAS | 78860-34-1 |
| Molecular Formula | C32H30N2O4 |
| Quantity | 5 mg |
| Synonym | demethylasterriquinone b1, dmaq-b1, daq b1, 2,5-dihydroxy-3-7-3-methyl-but-2-enyl-1h-indol-3-yl-6-2-1,1-dimethyl-allyl-1h-indol-3-yl-1,4 benzoquinone, 2-2-1,1-dimethylallyl-1h-indol-3-yl-3,6-dihydroxy-5-7-3-methylbut-2-enyl-1h-indol-3-yl 1,4 benzoquinone, tocris-1819, 2,5-cyclohexadiene-1,4-dione, 2-2-1,1-dimethyl-2-propenyl-1h-indol-3-yl-3,6-dihydroxy-5-7-3-methyl-2-butenyl-1h-indol-3-yl, 2,5-cyclohexadiene-1,4-dione,2-2-1,1-dimethyl-2-propen-1-yl-1h-indol-3-yl-3,6-dihydroxy-5-7-3-methyl-2-buten-1-yl-1h-indol-3-yl, 2,5-dihydroxy-3-2-2-methylbut-3-en-2-yl-1h-indol-3-yl-6-7-3-methylbut-2-enyl-1h-indol-3-yl cyclohexa-2,5-diene-1,4-dione, 2,5-dihydroxy-3-7-3-methylbut-2-en-1-yl-1h-indol-3-yl-6-2-2-methylbut-3-en-2-yl-1h-indol-3-yl cyclohexa-2,5-diene-1,4-dione |
| InChI Key | XMGNJVXBPZAETK-UHFFFAOYSA-N |
| SMILES | CC(=CCC1=CC=CC2=C1NC=C2C3=C(C(=O)C(=C(C3=O)O)C4=C(NC5=CC=CC=C54)C(C)(C)C=C)O)C |
| IUPAC Name | 2,5-dihydroxy-3-[2-(2-methylbut-3-en-2-yl)-1H-indol-3-yl]-6-[7-(3-methylbut-2-enyl)-1H-indol-3-yl]cyclohexa-2,5-diene-1,4-dione |
| Molecular Weight (g/mol) | 506.602 |
| PubChem CID | 3013166 |
| Formula Weight | 506.59 |
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